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KMID : 0363320100310020290
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Journal of Korean Oriental Internal Medicine
2010 Volume.31 No. 2 p.290 ~ p.297
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Experimental Study on the Antioxidant and Antimicrobial Properties of Dioscoreae Rhizoma
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Choi Ga-Young
Kim Byoung-Woo
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Abstract
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Objectives : This study evaluated the effect of Dioscoreae Rhizoma on antioxidant and antimicrobial activity in vitro.
Methods : In vitro experiments were made on antioxidant by DPPH radical scavenging activity, enzyme activity of SOD, protective effect about and DNA fragmentation in RAW264.7 cells, as well as antimicrobial by Cox-2 expression in LPS-induced RAW264.7 cells.
Results : 1. Dioscoreae Rhizoma’s antioxidant ability was improved by DPPH radical scavenging activity. 2. Antioxidant ability of Dioscoreae Rhizoma produced good results at more than 0.025 mg/. 3. On protective effect of Dioscoreae Rhizoma about on RAW264.7 cells, with addition of Dioscoreae Rhizoma extract the cells’ survival increased compared to adding only. 4. About revelation-control of Cox-2 at RAW264.7 cells which induce by LPS, when Dioscoreae Rhizoma’s concentration was higher from 0.0125 mg/ to 1 mg/, its control activity was stronger. Thus we found Dioscoreae Rhizoma has antimicrobial activity. 5. The power of DNA fragmentation control of Dioscoreae Rhizoma was time-independent.
Conclusions : From this study we conclude that Dioscoreae Rhizoma has effects on antioxidant and antimicrobial activity. However, considerable work still needs to be done studying antioxidants by concentration, as well as a variety of experiments about antimicrobial activity.
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KEYWORD
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Dioscoreae Rhizoma, antioxidant, antimicrobial activity
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